88-2B chemokine receptor amino acid sequence coding purified and insulated polynucleotide, RNA transcript, biologically active vector, host cell, the method for manufacture of 88-2B polypeptide, 88-2B polypeptide coding polynucleotide, purified and insula

摘要

The present invention provides polynucleotides that encode the chemokine receptors 88-2B and materials and methods for the recombinant production of these chemokine receptors. Also provided are assays utilizing the polynucleotides which facilitate the identification of ligands and modulators of the chemokine receptors. Receptor fragments, ligands, modulators, and antibodies are useful in the detection and treatment of disease states associated with the chemokine receptors such as atherosclerosis, rheumatoid arthritis, tumor growth suppression, asthma, viral infection, AIDS, and other inflammatory conditions.