Solid Pharmaceutical compositions comprising a combination of ethinylestradiol and Drospirenone, a Surfactant Agent with suitable content uniformity and Dissolution rate of the drug not Insured for Micronized, procedure

摘要

The present Invention relates to a Pharmaceutical composition, ensuring speed of Dissolution and homogenization of Micronized Drugs not achieving a Physicochemical stability inesperada.tambiu00e9n with the pharmaceutical composition obtained by this process and the use of com Pharmaceutical training to prepare a Medicine.The pharmaceutical composition comprises a combination of two active substances, namely drospirenone and ethinyl estradiol, a Surfactant Agent and pharmaceutically acceptable excipients on condition that Drospirenone present the following Distribution: approximately 95% of it S have a particle size less than 100 UM (microns)Approximately 26 per cent present a particle size of less than 20 um (microns) and approximately 15% present a particle size less than 10 um (microns), or to the condition that the active principles present in a surface area less 10000cm2 / g or with Provided that Drospirenone is not in Micronized form.This composition is used to inhibit ovulation and changes in cervical secretion.