PROCEDURE FOR OBTAINING DAILY CREAM PREPARATION BASED ON THE COMBINATION OF BIOACTIVE COMPONENTS USED IN TREATMENT OF AGED SKIN

摘要

Procedure for obtaining daily cream preparation based on the combination of bioactive components used in treatment of aged skin is characterized by that aqueous phase (30,00 - 90,00 mass %), is heated at 40 - 85 °C, where hydrophile components are dissolved: propylenglycol (2,00 - 30,00 mass %), imidazolidinylurea (0,05 - 0,60 mass %), polysorbate 60 (0,05 - 5,00 mass %), is added during oily phase heated up to the temperature 45 - 85 °C with lipophylic components: sorbitan stearate and stearic acid (0,05 - 5,00 mass %), octylmethoxysicinamate (0,50 - 7,50 mass %) C12 - C15 of alkyl benzoate, (0,01 - 0,10 mass %) , 4-metylbenzylidene camphor (0,5 - 5,00 mass %), jojoba oil (0,50 - 0,60 mass %). When cooled with permanent mixing up to the temperature in range of 50 - 55 °C, the remaining ingredients are added: butyhydoxytoluene, (0,05 - 0,60 mass %) (0,01 - 0,60 mass %) phenoxyethanol-methyl-ethyl-ethyl-propyl-paraben (0,20 -5,00 mass %), vitamin E acetate, omega 6 polyunsaturated acids (0,35- 1,05 mass %), vitamin A palmitate (0,005 - 0,45 mass %), hydrolyzed collagen 0,2 - 1,50 mass %), hydrolyzed elastine (0,20 - 1,50 mass %), provitamin B5 (0,20 -5,00 mass %), and hyaluronic acid (0,01 - 0,05 mass %) and continue with mixing and cooling up to about 40 °C , and then add (0,10 - 0,50 mass %) of scented component and continue with mixing at the speed of 50 rpm, during 30 minutes, where a cream of homogenous appearance, fragrance having origin in the scented component is obtained, and its pH value range is within 4,5 - 8,0.;Postupak za dobijanje dnevne kreme na bazi kombinacije bioaktivnih komponenti koje se koriste u tretmanu zrele koe okarakterisan je time to se vodena faza (30,00-90,00 mas.%), zagrejana na 40-85В°C, u kojoj su rastvorene hidrofilne komponente: propilenglikol (2,00-30,00 mas.%), imidazolidinilurea (0,05-0,60 mas.%), polisorbat 60 (0,05-5,00 mas.%), dodaje u uljanu fazu zagrejanu na temperaturi 45-85В°C sa lipofilnim komponentama: sorbitan stearata (0,05-5,00 mas.%), oktilmetoksicinamata (0,50-7,50 mas.%), C12-C15 alkil benzoata, (0,01-0,10 mas.%), 4-metilbenziliden kamfora (0,5-5,00 mas.%), Jojoba ulje (0,50-15,00 mas.%). Kada se ohladi uz konstantno meanje do temperature u opsegu 50-55В°C, dodaju se preostali sastojci: butilhidroksitoluola, (0,05-0,60 mas.%) (0,01-0,60 mas.%) fenoksietanola-metil-etil-etil-propil-parabena, (0,20-5,00 mas.%), vitamin E acetata omega 6 polinezasienih kiselina (0,35-1,05 mas.%), vitamin A palmitata (0,005-0,45 mas.%), hidrolizovani kolagen (0,2-1,50 mas.%), hidrolizovani elastin (0,20-1,50 mas.%), provitamin B5 (0,20-5,00 mas.%), i hijaluronska kiselina (0,01-0,05 mas.%), i produi se sa meanjem i hlaenjem do temperature oko 40В°C, a zatim se dodaje (0,10-0,50 mas.%) mirisne komponente i nastavi se sa meanjem pri brzini od 50 rpm, u vremenu od 30 minuta, pri emu se dobija krema homogenog izgleda, i mirisa koji potie od mirisne komponente, ija se pH vrednost kree u granicama 4,5-8,0.[Procedure for obtaining daily cream preparation based on the combination of bioactive components used in treatment of aged skin is characterized by that aqueous phase (30,00 - 90,00 mass %), is heated at 40 - 85 В°C, where hydrophile components are dissolved: propylenglycol (2,00 - 30,00 mass %), imidazolidinylurea (0,05 - 0,60 mass %), polysorbate 60 (0,05 - 5,00 mass %), is added during oily phase heated up to the temperature 45 - 85 В°C with lipophylic components: sorbitan stearate and stearic acid (0,05 - 5,00 mass %), octylmethoxysicinamate (0,50 - 7,50 mass %) C12 - C15 of alkyl benzoate, (0,01 - 0,10 mass %) , 4-metylbenzylidene camphor (0,5 - 5,00 mass %), jojoba oil (0,50 - 0,60 mass %). When cooled with permanent mixing up to the temperature in range of 50 - 55 В°C, the remaining ingredients are added: butyhydoxytoluene, (0,05 - 0,60 mass %) (0,01 - 0,60 mass %) phenoxyethanol-methyl-ethyl-ethyl-propyl-paraben (0,20 -5,00 mass %), vitamin E acetate, omega 6 polyunsaturated acids (0,35- 1,05 mass %), vitamin A palmitate (0,005 - 0,45 mass %), hydrolyzed collagen 0,2 - 1,50 mass %), hydrolyzed elastine (0,20 - 1,50 mass %), provitamin B5 (0,20 -5,00 mass %), and hyaluronic acid (0,01 - 0,05 mass %) and continue with mixing and cooling up to about 40 В°C , and then add (0,10 - 0,50 mass %) of scented component and continue with mixing at the speed of 50 rpm, during 30 minutes, where a cream of homogenous appearance, fragrance having orig