MEDICINAL COMPOSITIONS ADHERING TO STOMACH/DUODENUM

摘要

THE PRESENT INVENTION PROVIDES A GASTRIC AND/OR DUODENAL ADHESIVE PHARMACEUTICAL COMPOSITION OBTAINED BY COATING A COMPOSITION, WHICH COMPRISES A MEDICAMENT ACTING AT THE STOMACH AND/OR DUODENUM AND ONE OR MORE OF INGREDIENTS SELECTED FROM WATER INSOLUBLE POLYMERS, POLYGLYCERIN FATTY ACID ESTERS, LIPIDS AND WAXES, WITH A POLYMER HAVING ADHESIVE CAPACITY ONTO THE SURFACE OF THE MUCOSA OF A DIGESTIVE TRACT UNDER ACID CONDITIONS AND SEPARATES FROM THE MUCOSA OF THE DIGESTIVE TRACT IN NEUTRAL OR ALKALINE CONDITIONS. THIS COMPOSITION ADHERES ONLY TO THE MUCOSA OF THE STOMACH AND/OR DUODENUM AND RELEASES THE MEDICAMENT OVER LONG HOURS SO THAT SUFFICIENT EFFECTS ARE AVAILABLE BY A SMALL AMOUNT OF THE MEDICAMENT. FIGURE 1