SUSTAINED DELIVERY OF LEUPROLIDE USING AN IMPLANTABLE SYSTEM

摘要

THE INVENTION IS DIRECTED TO A DEVICE FOR DELIVERING AN ACTIVE AGENT FORMULATION FOR A PREDETERMINED ADMINISTRATION PERIOD. AN IMPERMEABLE RESERVOIR (12) IS DIVIDED INTO A WATER-SWELLABLE AGENT CHAMBER AND AN ACTIVE AGENT FORMULATION CHAMBER. FLUID FROM THE ENVIRONMENTS IS IMBIBED THROUGH A SEMIPERMEABLE PLUG INTO THE WATER-SWELLABLE AGENT CHAMBER AND THE ACTIVE AGENT FORMULATION IS RELEASED THROUGH A BACK-DIFFUSION REGULATING OUTLET (22) DELIVERY PERIODS OF UP TO 2 YEARS ARE ACHIEVED. (FIG.1)