首页> 外国专利> PYRAZINOCHINOXALINE DERIVATIVES AS SEROTONINE AGONISTS AND ANTAGONISTS

PYRAZINOCHINOXALINE DERIVATIVES AS SEROTONINE AGONISTS AND ANTAGONISTS

机译:吡嗪并几恶灵衍生物作为5-羟色胺激动剂和拮抗剂

摘要

The present invention is directed to novel compounds represented by structural Formulas (I) and (I-a):or a pharmaceutically acceptable salt thereof, wherein R1, R4a, R4b, R5, R6, R7, R8, R9, n, and X are described herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are serotonin agonists and antagonists and are useful in the control or prevention of central nervous system disorders including obesity, anxiety, depression, psychosis, schizophrenia, sleep and sexual disorders, migraine and other conditions associated with cephalic pain, social phobias, and gastrointestinal disorders such as dysfunction of the gastrointestinal tract motility.
机译:本发明涉及由结构式(I)和(Ia)表示的新化合物:或其药学上可接受的盐,其中R 1,R 4a,R 4b,R 5,R 5本文描述了6,R 7,R 8,R 9,n和X。本发明还涉及包含这些新型化合物作为活性成分的药物制剂,以及该新型化合物及其制剂在治疗某些疾病中的用途。本发明的化合物是5-羟色胺激动剂和拮抗剂,可用于控制或预防中枢神经系统疾病,包括肥胖,焦虑,抑郁,精神病,精神分裂症,睡眠和性疾病,偏头痛和其他与头痛,社交恐惧症有关的疾病。以及胃肠道疾病,例如胃肠道运动功能障碍。

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