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PHARMACEUTICAL COMPOSITION CONTAINING FUROSEMIDE AND CONIVAPTAN FOR THE TREATMENT OF THE CONGESTIVE HEART FAILURE
PHARMACEUTICAL COMPOSITION CONTAINING FUROSEMIDE AND CONIVAPTAN FOR THE TREATMENT OF THE CONGESTIVE HEART FAILURE
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机译:包含呋塞米和CONIVAPTAN的药物组合物治疗慢性充血性心力衰竭
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摘要
Combinations of diuretics and vasopressin antagonists are useful to slow and reverse the symptoms and process of congestive heart failure, to increase the excretion of water in the urine, and to decrease the excretion of sodium and potassium ions in urine. Preferred vasopressin antagonists have the formula (I) wherein R and R5 are hydrogen or lower alkyl; R1, R2, and R3 are hydrogen, halo, alkyl, alkoxy, and amino; and R4 is hydrogen or phenyl, and a pharmaceutically acceptable salt thereof.
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机译:利尿剂和血管加压素拮抗剂的组合可用于减缓和逆转充血性心力衰竭的症状和过程,增加尿液中水的排泄,并减少尿液中钠和钾离子的排泄。优选的加压素拮抗剂具有式(I),其中R和R 5为氢或低级烷基; R 1,R 2和R 3为氢,卤素,烷基,烷氧基和氨基; R 4为氢或苯基及其药学上可接受的盐。
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