NEW PEPTIDE COMPOSITIONS AND THEIR USE, IN PARTICULAR FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS ACTING AGAINST THE HEPATITIS C VIRUS

摘要

Peptide composition (X) comprising at least two of four specified peptides, is new. Peptide composition (X) comprising at least two of four specified peptides (A), (B), (C) and (D) that contain, respectively, at least sequences (1), (45), (127) and (172), is new. Xaa1-Ala-Xaa2-Gln-Gly-Tyr-Lys-Val-Xaa3-Val-Leu-Asn-Pro-Ser-Val-Xaa4-Ala-Thr-Leu-Xaa5-Phe-Gly-Xaa6-Tyr-Met-Ser-Lys-Ala-Xaa7-Gly-Xaa8 (1) Gly-Xaa18-Xaa19-Xaa20-Xaa21-Xaa22-Xaa23-Thr-Ser-Leu-Thr-Gly-Arg-Asp-Xaa24-Asn-Xaa25-Xaa26-Xaa27-Gly-Glu-Xaa28-Gln-Xaa29-Xaa30-Ser-Thr-Ala-Xaa31-Xaa32-Xaa33-Phe-Leu-Xaa34-Xaa35-Xaa36-Xaa37-Asn-Gly-Xaa38-Xaa39-Trp-Thr-Val-Xaa40 (45) Ser-Xaa47-Met-Xaa48-Phe-Thr-Xaa49-Xaa50-Xaa51-Thr-Ser-Pro-Leu-Xaa52-Xaa53-Xaa54-Xaa55-Thr-Leu-Xaa56-Phe-Asn-Ile-Xaa57-Gly-Gly-Trp-Val-Ala-Xaa58-Gln-Xaa59 (127) Xaa69-Lys-Xaa70-Ala-Arg-Xaa71-Ile-Val-Xaa72-Pro-Xaa73-Leu-Gly-Xaa74-Arg-Val-Cys-Glu-Lys-Xaa75-Ala-Leu-Xaa76-Xaa77-Val-Xaa78-Xaa79-Xaa80-Xaa81 (172) Xaa1 and Xaa7 = Tyr or His; Xaa2 = Ala, Gly or Thr; Xaa3 = Arg or Leu; Xaa4 = Ala or Thr; Xaa5 = Gly or Ser; Xaa6 = Ala, Thr or Val; Xaa8 = Ile, Thr, Met or Val; Xaa18 and Xaa30 = Leu or Val; Xaa19 = Leu or Phe; Xaa20 = Gly or Ser; Xaa21 = Cys or Thr; Xaa22 and Xaa23 = Ile or Val; Xaa24 = Lys, Arg or Thr; Xaa25 = Gln or Glu; Xaa26 = Val or Asn; Xaa27 = Asp, Glu or Cys; Xaa28 and Xaa38 = Val or Ala; Xaa29 = Val, Ile, Glu or Met; Xaa31 = Thr, Lys or Ala; Xaa32 = Gln or His; Xaa33 and Xaa35 = Ser or Thr; Xaa34 = Ala or Gly; Xaa36 = Cys or Ala; Xaa37 = Val, Ile or Thr; Xaa39 = Cys or Met; Xaa40 = Tyr or Phe; Xaa47 = Leu or Pro; Xaa48, 49, 50 and 58 = Ala or Ser; Xaa51 = Ile or Val; Xaa52 = Thr, Ser or Ala; Xaa53 = Thr or Ile; Xaa54 = Gln, Ser or Gly; Xaa55 = Asn, Gln, His, Ser, Tyr or Thr; Xaa56 = Leu or Met; Xaa57 = Leu or Trp; Xaa59 = Leu, Pro or Ile; Xaa69 = Arg or Gln; Xaa70 = Pro or Ala; Xaa71 = Leu or Phe; Xaa72 = Phe or Tyr; Xaa73 = Asp or Glu; Xaa74 = Val or Ser; Xaa75 = Met or Arg; Xaa76 = Tyr or His; Xaa77 = Asp or Asn; Xaa78 = Val or Ile; Xaa79 = Ser, Thr or Lys; Xaa80 = Thr, Lys, Ile or Asn; Xaa81 = Leu or Thr. Independent claims are also included for: (1) peptides (A)-(D), containing at least the specified sequences; (2) nucleic acid (I) encoding (A)-(D); (3) expression vector containing at least one (I); (4) microorganism or host cell transformed with at least one vector of (3); (5) antibodies (Ab) directed against at least one of (A)-(D) or composition (X); and (6) detection and/or quantitation of hepatitis C virus.