PHARMACEUTICAL COMPOSITIONS FOR CARDIAC INSUFFICIENCY THERAPY.

摘要

Medication for the treatment of cardiopathies of the group consisting of primary cardiomyopathies and secondary cardiomyopathies, characterized in that it contains the nucleic acid sequence or sequences encoding one or multiple S100 proteins of the group consisting of S100A1, S100A2, S100A3, S100A4, S100A5, S100A6, S100A7 , S100A8, S100A9, S100A10, S100A11, S100A12 and S100A13, one or multiple mutants thereof, with a homology with respect to them of at least 60%, which increase the release of systolic Ca2 + from the sarcoplasmic reticulum and accelerate the reabsorption of Ca2 + in the sarcoplasmic reticulum, or encoding one or multiple hydrophobic peptides of the group consisting of peptides according to SEQ ID NO: 36 and 39, in which the nucleic acid sequence (s) are optionally formulated with pharmaceutically adjuvants and / or vehicles acceptable.