PIRIDINUM COMPOUNDS USEFUL FOR THE TREATMENT OF AGE-RELATED DISEASES.

摘要

The main objective of the present invention is to provide a new class of pyridinium series compounds that are useful for the management of diabetes and vascular complications related to aging, and particularly in the treatment of complications of diabetes mellitus and other aging-related conditions that include kidney disease, nerve damage, arteriosclerosis, retinopathy and dermatological conditions. The invention also extends the method for reversing the discoloration of teeth, resulting from non-enzymatic blackening in the oral cavity, which comprises the administration of an effective amount to reverse the preformed cross-links of advanced glycosylation, etc. Another object of the present invention is to provide pyridinium series compounds, which exhibit breakdown activities of AGEs. Still another object of the present invention is to provide a method for the preparation of pyridinium series compounds that exhibit AGE breakdown activities. Still another object of the invention is to provide pharmaceutical compositions with a new class of pyridinium series compounds according to the invention and their pharmaceutically acceptable salts, in combination with suitable carriers, solvents, excipients, diluents, and other means. normally used for the preparation of such compositions.