DERIVATIVES OF 1,2-DIAZEPAN AS INHIBITORS OF THE CONVERTER ENZYME OF INTERLEUQUINA-1 BETA.

摘要

A compound represented by the ** formula ** in which m is 0 or 1; W is -CH2-, -C (O) -, S (O) 2 or -S (O) -; X is -C (H) -, -C (R8) -, or Z is -CH2-, -O-, -S-, or -N (R1) -, provided that if Z is - N (R1 ) -, then W is -C (O) -, -S (O) 2- or -S (O) -; each R1 is, separately, -H, -S (O) 2-CH3, R2 is -C (O) R8, -C (O) C (O) R8, -S (O) 2R8, -S (O ) R8, -C (O) OR8, - C (O) N (H) R8, -S (O) 2N (H) -R8, -S (O) N (H) -R8, -C (O) C (O) N (H) R8, - C (O) CH = CHR8, -C (O) CH2OR8, -C (O) CH2N (H) R8, -C (O) N (R8) 2, - S (O) 2N (R8) 2, -S (O) N (R8) 2, -C (O) C (O) N (R8) 2, -C (O) CH2N (R8) 2, -CH2-R8 , -CH2-alkenyl-R8 or -CH2-alkynyl-R8; R8 is -H, an amino acid side chain, each R4 is independently -OH, -F, -CI, -Br, -I, -NO2, -CN, -NH2, -CO2H, -C (O) NH2, - N (H) C (O) H, -N (H) C (O) NH2, - alkyl, -cycloalkyl, -perfluoroalkyl, -O-alkyl, - N (H) alkyl, -N (alkyl) 2, - C (O) N (H) alkyl, - C (O) N (alkyl) 2, -N (H) C (O) alkyl, -N (H) C (O) N (H) alkyl, - N ( H) C (O) N (alkyl) 2, -S-alkyl, -S (O) 2alkyl, -S (O) alkyl, -C (O) alkyl, -CH2NH2, -CH2N (H) alkyl, - CH2N (alkyl) 2 oN (H) C (O) Oalkyl; R5 is -OH, -OR8, -N (H) OH or -N (H) SO2R8; R6 is -H, -CH2OR9, -CH2SR10, -CH2N (H) R9, -CH2N (R9) R11, - C (H) N2, -CH2F, -CH2CI, -CH2Br, -CH2I, -C (O) N (R11) 2, -R13 or -R14.