Set of derivatives of 2-(2-(pyridylmethylsulphinyl)-(benzimidazole) comprises products of selective oxidation of 2-(2-(pyridylmethylthio)-benzimidazole by e.g. alkali metal hypochlorite

摘要

Preparing 2-(2-pyridylmethylsulfinyl)benzimidazole derivative or its salt, solvate, and hydrate, comprises subjecting sulfide compound or its salt or solvate to an oxidation reaction with alkali metal hypochlorite and an alkali metal hydroxide where the solvent is an 1-6C alkyl ester. Preparing 2-(2-pyridylmethylsulfinyl)benzimidazole derivative of formula (I) or its salt, solvate, and hydrate, comprises subjecting sulfide compound of formula (II) or its salt or solvate to an oxidation reaction with alkali metal hypochlorite and an alkali metal hydroxide where the solvent is an 1-6C alkyl ester. R1, R2, R3 : H, 1-3C alkyl, 1-3C alkoxy which may optionally be substituted by one or more F, and 3-1-3C alkoxy-1-3C-alkoxy; and R4 : a radical selected from H and 1-3C-alkoxy, which may optionally be substituted by one or more F. [Image].