CONDENSED IMIDAZOL COMPOUNDS AND MEDICINES AGAINST MELLITUS DIABETES.

摘要

A condensed imidazole compound, a pharmacologically acceptable salt thereof or hydrates thereof, which is represented by formula (I), (in which R1 represents hydrogen or the formula -NR4R5 (in which R4 and R5 are the same or different each other and each represents hydrogen, a C3-C8 cycloalkyl group or or a CC1-C8 alkyl group; R2 represents 1) hydrogen, 2) a halogen atom, 3) a C2-C8 alkynyl group that may be substituted with a C3-C6 hydroxyl or cycloalkyl group, 4) a C1-C8 alkyl group or 5) a C1-C8 alkoxy group; R3 represents a 1,2-dihydro-2-oxopyridyl group which may be substituted with a) a halogen atom or a C1-C6 alkyl group, and and whose nitrogen atom may be further substituted with b-1) a C1- alkyl group C6 which may be substituted with a halogen, hydroxyl, phenyl, C2-C8 alkenyl or an optionally protected carboxyl group, b-2) an optionally substituted C3-C6 cycloalkyl group or b-3) a C3 cycloalkyl group -C6 optionally substituted; Ar represents 1) an optionally substituted phenyl group, 2) an optionally substituted pyridyl group, 3) an optionally substituted furyl group or 4) an optionally substituted thienyl group; and both Q and W are N or one of Q and W is N and the other is CH;