PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF DAMAGE TO FABRICS DUE TO ARTERIAL IRRIGATION DEFECTS.

摘要

The present invention relates to human medicine and in particular to a pharmaceutical combination of Epidermal Growth Factor (EGF) and a mimetic peptide of growth hormone release factor (GHRP), which is useful in prevention and / or restoration of tissue damage that is caused by lack of blood supply to a particular organ due to different pathological conditions. The said combination can be used within the same pharmaceutical composition or applied to the same individual separately as part of a single treatment that favors cellular vitality in organs when they are partially or totally deprived of the supply of oxygenated blood for a period. weather. This combination also attenuates the formation of toxic species and metabolites in these organs, so it is particularly useful in tissues subject to prolonged periods of ischemia. The pharmaceutical combination can also be applied prophylactically in connective subjects that can lead to dysfunction or multiple damage of organs of diverse origin such as burned, polytrauma, respiratory distress syndrome, hypoxic infants, hypovolemic shock, necrotizing enterocolitis, as well as to subjects undergoing major surgical interventions.