USE OF AN ANTIINTERLEUQUINE ANTIBODY 9 FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF ASTHMA.

摘要

A VARIATION OF C TO T IN DNA AT POSITION 3365 IN EXON 5 OF THE FACTOR ASSOCIATED WITH HUMAN ASTHMA 1 (AAF1) PRODUCES THE PRE-AMINO ACID REPLACEMENT OF A TREONINE FOR A METIONIN IN CODON 117 OF AAF1. WHEN THIS REPLACEMENT IS PRODUCED IN BOTH ALLOYS OF AN INDIVIDUAL, IT IS ASSOCIATED WITH A LOWER EVIDENCE OF ATOPIC ALLERGY INCLUDING ASTHMA, LOWER CUTANEOUS RESPONSES ABOUT TESTS AND A LOWER TOTAL IGE IN SERUM. IN THIS MODE, THE APPLICANT HAS IDENTIFIED THE EXISTENCE OF A NON-ASTHMATIC PHENOTYPE NOT CHARACTERIZED BY A METIONIN IN CODON 117 WHEN IT IS PRODUCED IN BOTH PRODUCTS OF THE AAF1 GENE IN AN INDIVIDUAL.