HETEROCYCLIC LIGANDS AND THE GADOLINIUM (III) COMPLEXES THEREOF WITH BIOMEDICAL APPLICATIONS

摘要

The invention relates to compounds having general formula A and the paramagnetic complexes of Gd(III) and of other lanthanides thereof which are used as contrast agents for magnetic resonance imaging. More specifically, the invention relates to compounds having general formula A, wherein R1 and/or R2 are hydrogens, methyl groups, nitre groups and amino groups. The invention further relates to a method of obtaining said compounds from the corresponding bromoethylpyrazoles, comprising the following steps: 1) alkylation of the original amine 2) deprotection of the tert-butoxycarbonylamino groups 3) alkylation of the amino groups with methyl bromoacetate and, finally, 4) basic hydrolysis which produces the tetrasodium salt. The invention relates to complexes of Gd(III) and of other lanthanides derived from compounds having general formula A, to the method of obtaining said complexes and to the experimental and clinical use of same in the production of contrast agents for clinical diagnosis by means of magnetic resonance imaging.