VANILOID ANALOGS CONTAINING RESINIFERATOXINE PHARMACOPHORES AS AGONIST SPEAKERS OF THE VANILOID RECEPTOR AND ANALGESIC, COMPOSITIONS AND USES OF THE SAME.

摘要

Compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein, X is oxygen or sulfur; A is ¿NHCH2- or ¿CH2-; R1 is C1-4 alkylaryl or R4CO-, wherein R4 is C1-18 alkyl, C2-18 alkenyl, or C6-10 aryl; R2 is C1-6 alkyl, C1-6 alkoxide, haloalkyl or halogen; R3 is hydrogen, C1-4 alkyl, aminoalkyl, diacid monoester or -alkyl acid and the asterisk indicates a chiral carbon atom.