Fusion proteins containing stress proteins to induce immune responses.

摘要

THE PRESENT INVENTION REFERS TO A VACCINE, INTENDED TO INDUCE AN IMMUNE ANSWER DIRECTED AGAINST AN ANTIGEN OF A VERTEBRATE (FOR EXAMPLE A MAMMER), AND THAT INCLUDES AN ANTIGEN AS WELL AS ALL OR PART OF A PROTEIN OF THIS OR A PART OF THIS OR A PART PROTEIN THAT HAS A SEQUENCE OF AMINED ACIDS IS SUFFICIENTLY APPROVED TO THE SEQUENCE OF AMINATED ACIDS OF STRESS PROTEIN, IN ORDER TO INDUCE THE IMMUNE RESPONSE DIRECTED AGAINST ANTIGEN. IN AN EMBODIMENT, THIS INVENTION CONCERNS VACCINES AND COMPOSITIONS THAT INDUCE AN ANSWER OF CYTOTOXIC T-LYMPHOCYTES (CTL) IN A MAMMER AND UNDERSTAND AN ANTIGEN OR ALL OR PART OF A STRESS PROTEIN. IN ANOTHER MODE OF EMBODIMENT, THIS INVENTION REFERS TO VACCINES AND COMPOSITIONS THAT INDUCE AN IMMUNE ANSWER DIRECTED AGAINST THE VIRUS OF THE INFLUENZA IN A MAMMER AND THAT INCLUDES AN ANTIGEN OF THE VIRUS OF THE INFLUENZA AS WELL AS ALL OR PART OF ONE OR VARIOUS FROM STRESS THIS INVENTION REFERS TO ALSO A VACCINE AND A COMPOSITION INTENDED TO INDUCE AN ANSWER ASSOCIATED WITH A CTL, AND THAT INCLUDES AN ANTIGEN ASSOCIATED WITH THIS TUMOR AS WELL AS ALL OR PART OF A PROTEIN, AS IS VACCINES AND COMPOSITIONS INTENDED TO DELETE IMMUNE ALLERGIC RESPONSES TO ALLERGENS AND UNDERSTANDING AN ALLERGEN AS WELL AS ALL OR PART OF A STRESS PROTEIN.