PROCEDURE OF PRODUCTION OF PARTICLES WITH AN AMORFA AND / OR METASTABLE CRYSTALLINE REGION CONVERTED TO CRYSTAL STATE.

摘要

A method for converting metastable amorphous and / or crystalline regions of preformed particles into an essentially crystalline state, comprising: (a) placing the undissolved preformed particles in a suitable apparatus to withstand supercritical or subcritical conditions; (b) treating the particles with a supercritical or subcritical fluid comprising an anti-solvent and a solvent; and (c) recover essentially crystalline particles.