RESOLUTION OF TRANS-2-(ALKOXYCARBONYLETHYL)-LACTAMS USEFUL IN THE SYNTHESIS OF 1-(4-FLUOROPHENYL)-3(R)-3(S)-HYDROXY-3-(4-FLUOROPHENYL)-PROPYL)-4(S)-(4-HYDROXYPHENYL)-2-AZETIDINONE

摘要

A process for the microbiological or enzymatic hydrolytic resolution ofracemic traps-2-(alkoxycarbonylethyl)-lactams of formula(I) wherein R is C1-C7 alkyl, 2,2,2-trifluoroethyl or methoxyethoxyethyl andRL is hydrogen or a protecting group is disclosed, wherebyan optically enriched compound of formula (Ib) or (IIa) is obtained.