INHIBITION OF MIR-122 IN HEPATITIS C VIRUS INFECTED SUBJECTS AND CELLS

摘要

Methods and compositions for reducing viral genome amounts in a target cellare provided. In the subject methods, the activity of a miRNA is inhibited ina manner sufficient to reduce the amount of viral genome in the target cell,e.g., by introducing a miRNA inhibitory agent in the target cell. Alsoprovided are pharmaceutical compositions, kits and systems for use inpracticing the subject methods. The subject invention finds use in a varietyof applications, including the treatment of subjects suffering from a viralmediated disease condition, e.g., an HCV mediated disease condition.