METHODS FOR DETECTING A CHANGE IN THE CONFORMATIONAL OR ENERGETIC STATE OF A MOLECULAR SPECIES

摘要

The invention is a method for detecting a change in the conformational orenergetic state of a molecular species, comprising the steps of: (i)immobilising the molecular species, under conditions suitable for the reactionto occur; (ii) contacting at least part of the molecular species with alocalised electromagnetic field; and (iii) detecting a change in dielectricconstant during or after the reaction, to thereby detect a change in theconformational or energetic state of the molecular species.