USE OF C3A AND DERIVATIVES THEREOF AS A BIOMARKER FOR COLORECTAL ADENOMA AND/OR CARCINOMA; DIAGNOSIS METHOD AND TEST SYSTEM USING THE SAME

摘要

The present invention is directed to a method for detecting colorectal adenomaand/o( colorectal carcinoma comprising the steps: a) providing an isolatedsample material which has been taken from an individual, b) determining thelevel of C3a or a derivative thereof in said isolated sample material, c)comparing the determined level of C3a or a derivative thereof with one or morereference values. The invention is further directed to a method fordiscriminating between colorectal adenoma and colorectal carcinoma as well asto a method for monitoring the course of colorectal adenoma and/or colorectalcarcinoma and/or the treatment of colorectal adenoma and/or' colorectalcarcinoma. Moreover, the invention is directed to a test system and an arrayfor use in these methods. Furthermore, the invention is directed to the use ofC3a as a biomarker for a detection of colorectal adenoma and/or colorectalcarcinoma in an individual. Further, the invention is directed to method fordetermining whether a compound is effective in the treatment colorectaladenoma and/or colorectal carcinoma.