QUATERNARY ALKALOID DERIVATIVES OF CHELIDONIUM MAJUS L

摘要

The invention relates to alkaloid reaction products obtainable in a processwherein alkaloids are reacted with a derivatizing agent, preferably thiotepaor another one of the compounds listed in Fig.3, whereafter unreactedderivatizing agent and other water-soluble compounds are removed from thereaction mixture by washing with water or a suitable aqueous solvent,whereafter the reaction mixture is subjected to a treatment with strong acid,preferably hydrogen chloride (HCI), to precipitate a water soluble salt of thereaction products. The precipitated reaction products comprise at least onequaternary alkaloid derivative and are suitable as drugs for prophylactic ortherapeutic application, particularly in the treatment of immunological ormetabolic dysfunctions, and cancer.