2',3'-DIDEOXY-3'-C-HYROXYMETHYLCYTIDINE AND PRODRUGS THEREOF FOR THE TREATMENT OF DRUG ESCAPE MUTANT HIV

摘要

There is provided inter alia use of 2',3'-dideoxy-3'-hydroxymethylcytosine ora prodrug or salt thereof in the manufacture of a medicament for the treatmentof HIV infection wherein the reverse transcriptase of the HIV bears at leastone mutation that allows an obligate chain terminating nucleoside- ornucleotide phosphate to be excised from the nascent DNA strand by ATP- orpyrophosphate-mediated excision.