1,2,4-DITHIAZOLI(DI)NE DERIVATIVES, INDUCERS OF GLUTHATHIONE-S-TRANSFERASE AND NADPH QUINONE OXIDO-REDUCTASE, FOR PROPHYLAXIS AND TREATMENT OF ADVERSE CONDITIONS ASSOCIATED WITHCYTOTOXICITY IN GENERAL AND APOPTOSIS IN PARTICULAR

摘要

The present invention relates to 5-imino-5H-[1,2,4]-dithiazol-3-yl-amine and[1,2,4]- dithiazolidine-3,5-diylidene-diamine derivatives as inducers ofglutha-thione-S- transferase (GST) and NADPH quinone oxidoreductase (NQO), tomethods for the preparation of these compounds and to novel intermediatesuseful for the synthesis of said [1,2,4]-dithiazoli(di)ne derivatives. Theinvention also relates to the use of a compound disclosed herein for themanufacture of a medicament useful in the for prophylaxis and treatment ofadverse conditions associated with cytotoxicity in general and apoptosis inparticular. The invention relates to compounds of the general formula (I):wherein the symbols have the meanings given in the specification.