TETRAHYDRONAPHTHYRIDINE AND TETRAHYDROPYRIDO4,3-DPYRIMIDINE COMPOUNDS AND COMPOSITIONS THEREOF USEFUL IN THE TREATMENT OF CONDITIONS ASSOCIATED WITH NEUROLOGICAL AND INFLAMMATORY DISORDERS AND DISFUNCTIONS

摘要

Fused heterocyclic compounds are disclosed that have formula (1): where A, B,L, N, R1, R3, R4', Y and Z are as defined herein. The compounds andpharmaceutical compositions thereof are useful for the prevention andtreatment of a variety of conditions in mammals including humans, including byway of non-limiting example, pain, inflammation, cognitive disorders, anxiety,depression, and others.