Dibenzosberanyl piperazine derivatives and drug-resistance overcoming agents containing the derivatives

摘要

Dibenzosuberanyl piperazine derivatives represented by the following formula (I): CHEM wherein R represents an aliphatic hydrocarbon group, which may contain one or more heteroatom-containing substituent groups and may preferably contain 2 to 30 carbon atoms, and physiologically acceptable salts thereof; and medicinal compositions containing these dibenzosuberanyl piperazine derivatives and/or physiologically acceptable salts thereof. These compounds show effectiveness in allowing resistance-acquired causes of diseases to restore sensitivity to drug, that is, a resistance overcoming effect.