AUTOMATED SEPARATION, PURIFICATION AND LABELING SYSTEMS FOR 60CU, 61Cu and 64Cu RADIONUCLIDES AND RECOVERY THEREOF

摘要

A novel method for separating an irradiated SUP60/SUPCU orSUP61/SUPCU or SUP64/SUPCU respectively from a composition containing SUP60/SUPNi or SUP61/SUPNi or SUP64/SUPNi respectively therein comprises dissolving the irradiated SUP60/SUPCU or SUP61/SUPCU or SUP64/SUPCU in a solvent acid to form an acidic solubilized composition, feeding the acidic solubilized composition onto an ion exchange column and removing an eluent comprising SUP60/SUPNi or SUP61/SUPNi or SUP64/SUPNi ions. In an aspect the eluent is further processed for SUP60/SUPNi or SUP61/SUPNi or SUP64/SUPNi recovery and recycling to prepare future targets. In an aspect SUP60/SUPCU or SUP61/SUPCU or SUP64/SUPCU respectively is temporarily trapped into the ion exchange column resin and held for subsequent recovery by addition of 0.5 N HCl to elute out the SUP60/SUPCU or SUP61/SUPCU or SUP64/SUPCU for further use or labeling. An enhanced process for labeling compounds with highly SUP60/SUPCU or SUP61/SUPCU or SUP64/SUPCU comprises loading SUP60/SUPCU, SUP61/SUPCU and SUP64/SUPCU elute onto a concentrating cartridge, collecting the 0.5N HCl eluent and admixing therewith 10-µL of ligand and 3N HCl solution in a reaction line to form a SUP60 or 61 or 64/SUPCU labeled product. In an aspect a further purification step comprises loading 10-mL sterile water into the reaction line and through the CSUB18/SUB Sep-Pak cartridge to further purify the labeled product which is adherent in the cartridge and SUP60/SUPCU, SUP61/SUPCU and SUP64/SUPCU each as a separate and independent purified product.