AMIPHIPHYLIC PEPTIDE-PNA CONJUGATES FOR THE DELIVERY OF PNA THROUGH THE BLOOD BRAIN BARRIER

摘要

The invention provides molecules comprising a nucleic acid, a hydrophobic moiety and a positively charge moiety, useful in the delivery of a nucleic acid sequence across a cellular membrane. The invention further relates to the use of these molecules for the delivery of a nucleic acid sequence to the brain across the blood brain barrier for diagnostic and therapeutic applications.