METHOD FOR THE DETECTION OF A NEUROLOGICAL OR PSYCHIATRIC, DEMENTIAL DISEASE, ESPECIALLY ALZHEIMER'S DISEASE BY USE OF CHOLECYSTOKININ (CCK) -MOLECULES, CORRESPONDING SUBSTANCES AND DETECTION REAGENTS

摘要

The invention comprises CCK-proteins and CCK-protein fragments or corresponding nucleic acid molecules and their determination in biological samples from individuals suffering from neurological or psychiatric, demential diseases, especially Alzheimer's disease. Amino acid sequences are processed by specific proteolysis and may comprise postranslational modifications. Alterations of the concentrations of these substances indicate the presence of a neurological or psychiatric, demential disease especially Alzheimer's disease. The detection of these substances is furthermore suitable for monitoring of clinical studies or monitoring the disease progression. These substances are also suitable for therapy and prophylaxis of neurological or psychiatric, demential diseases especially Alzheimer's disease.