LIPOPOLYPLEX CONSTRUCT WITH AN INTEGRIN BINDING PEPTIDE FOR DELIVERY OF NUCLEIC ACIDS, PEPTIDES OR DRUGS

摘要

The invention provides a complex suitable for delivery of a biologically-active material to a cell, which complex comprises: (a) a lipid of formula: (III); wherein RI, R2, R3, B, Q and m are as defined herein; (b) a biologically-active material; and (c) an integrin-binding peptide. The invention also provides a complex suitable for delivery of a biologically-active material to a cell, which complex comprises: (a) a lipid of formula: (I); wherein R1, R2, X1, X2 and R5,are as defined herein; (b) a biologically-active material; and (c) an integrin-binding peptide of formula: [DNA-Binding]-[Spacer]k-[Ligand] wherein DNA-Binding, Spacer, k and Ligand are as defined herein.