BIODEGRADABLE AND BIOCOMPATIBLE CROSSLINKED POLYMER HYDROGEL PREPARED FROM PVA AND/OR PEG MACROMER MIXTURES

摘要

Biodegradable and biocompatible polymeric hydrogels based on the mixtures of poly(vinyl alcohol) and poly(ethylene glycol) macromers, and methods for their preparation and use, are disclosed. The polymerization may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked hydrogels include prevention of post-operative adhesions, surgical sealants, embolic therapies, controlled delivery of drugs, coating of medical devices such as vascular grafts, wound dressings and other medical applications.