Cosmetic use of at least one inhibitor of the RhoA kinase production and/or RhoA kinase activation as an agent for loosening the features and/or for relaxing the skin

摘要

Topically applicable cosmetic/dermatological composition (A) suited for relaxing the features of and/or for decontracting the skin, comprises a RhoA kinase production and/or activation inhibitor (I) comprising (R)(+)-trans-4-(1-aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide or 1-(5-isoquinolinesulfonyl) homopiperazine; and an adjuvant e.g. antioxidants, fragrances and fillers. Topically applicable cosmetic/dermatological composition (A) suited for relaxing the features of and/or for decontracting the skin, comprises a RhoA kinase production and/or activation inhibitor (I) comprising (R)(+)-trans-4-(1-aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide, 1-(5-isoquinolinesulfonyl) homopiperazine or its derivatives or analogues, together with an adjuvant (antioxidants, fragrances, fillers, UV-screening agents, pigments, odor absorbers or dyestuffs), which are formulated into physiologically acceptable medium. Independent claims are also included for: (1) a methodology for determining the identity of an inhibitor of RhoA kinase activation, comprising: placing a dermal equivalent, on a support, in a suitable culture medium which, comprises (I) to be identified; measuring the spontaneous contraction of a dermal equivalent treated with the inhibitor and comparing same with the spontaneous contraction of a control dermal equivalent untreated with the inhibitor; identifying the inhibitors for which the spontaneous contraction of the dermal equivalent in the presence of inhibitor is reduced by at least 3% relative to the spontaneous contraction of the dermal equivalent without inhibitor; and (2) a regime or regimen for: relaxing the features of and/or for decontracting the skin; smoothing the skin and/or attenuating the microrelief; or reducing and/or smoothing skin wrinkles, comprising administering (I), formulated into a physiologically acceptable medium. ACTIVITY : Dermatological. MECHANISM OF ACTION : RhoA kinase production inhibitor; RhoA kinase activation inhibitor.