首页>
外国专利>
SYNTHETIC PEPTIDES WITH ANTIMICROBIAL AND ENDOTOXIN NEUTRALIZING PROPERTIES FOR MANAGEMENT OF THE SEPSIS SYNDROME
SYNTHETIC PEPTIDES WITH ANTIMICROBIAL AND ENDOTOXIN NEUTRALIZING PROPERTIES FOR MANAGEMENT OF THE SEPSIS SYNDROME
展开▼
机译:具有防腐和内毒素中和特性的合成肽用于脓毒症的管理
展开▼
页面导航
摘要
著录项
相似文献
摘要
A peptide with an amino acid composition such that the peptide is amphipathic, cationic and forms a stable alpha-helix and has the following structure comprising at least 12 amino acidsA=an amino acid selected from the basic amino acids Lys,Arg or HisB=an amino acid selected from the aromatic amino acids Phe, Trp or TyrC=an amino acid selected from the group comprising the hydrophobic amino acids Leu, Ile, Val or Ala, andsaid peptide has either the orientation according to the formula or the retro orientation thereof, wherein at least 0-m of the repetitive sequence motifs (A2-B2-C1-A3) have the retro orientation and the remaining repetitive motifs (A2-B2-C1-A3) have the orientation as presented in the formula and wherein,R1-R2- and R3 are a number of amino acids, and whereinm=1-10, preferably 2-8, more preferably 2-5 andn=1-3, a pharmaceutical composition comprising such a peptide application thereof in treatment or diagnosis related to i.a. parasite infection topical and systemic tumors and septic shock.
展开▼