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Analysis and prediction of protein functional sub-types from protein sequence alignments
Analysis and prediction of protein functional sub-types from protein sequence alignments
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机译:从蛋白质序列比对分析和预测蛋白质功能亚型
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摘要
Here we present a method for analysis and prediction of functional sub-types from multiple protein sequence alignments. Given an alignment and set of proteins grouped into sub-types according to some definition of function, such as enzymatic specificity, the method identifies positions that are indicative of functional differences by subtraction of sequence profiles, and analysis of positional entropy in the alignment.
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