DEPRESSION OF HERG K+ CHANNEL FUNCTION IN MAMMALIAN CELLS AND APPLICATIONS TO THE CONTROL OF CANCER CELLS DIVISION

摘要

The use of an HERG channel inhibitor for controlling the proliferation of cancer cells. Examples of such HERG channel inhibitors include dofetilide, cisapride, E-4031 and a siRNA molecule targeting a sequence involved in the expression of an HERG channel. Other ERG channels are also targets for these inhibitors.