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LIVE ATTENUATED BACTERIAL VACCINE TO REDUCE OR INHIBIT CARRIAGE AND SHEDDING OF ENTEROHEMORRHAGIC ESCHERICHIA COLI IN CATTLE
LIVE ATTENUATED BACTERIAL VACCINE TO REDUCE OR INHIBIT CARRIAGE AND SHEDDING OF ENTEROHEMORRHAGIC ESCHERICHIA COLI IN CATTLE
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机译:牛减毒活疫苗,以减少或抑制牛肠出血性大肠杆菌的运输和播种
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摘要
The invention provides live, attenuated enterohemorrhagic Escherichia coli (EHEC) bacteria in which the Shiga toxin coding sequences are deleted to abolish Shiga toxin production and one or more of the nucleotide sequences for the bacterial adhesin protein intimin, the locus of enterocyte effacement encoded regulator, and the translocated intimin receptor are mutated to inactivate the activity of the encoded protein(s). This live, attenuated E. coli bacteria is used in a vaccine for reducing or inhibiting carriage and shedding of EHEC in cattle.
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