METHOD OF PRODUCING XENOGENIC CD4 T-CELL AND ANIMAL MODEL PRODUCING XENOGENIC CD4 T-CELL

摘要

The present invention relates to a method of producing CD4 T-cells and an animal model producing xenogenic CD4 T-cells. More specifically, the method concerns the production of CD4+CD8' T cells recognizing antigen presented by xenogenic major histocompatibility complex class (MHC-II) by transplantation of biological material containing cells having T cell differentiation capability and expressing xenogenic MHC II into immunodeficient animal. According to the present invention, because the animal including human can supplied with self immunocytes prepared by xenogenic animal, the present invention can be used for treating immune dysfunction-associated diseases such as infection, autoimmune disease, AIDS, and malignant tumor.