TREATMENT OF TUMORS WITH ACETYLENES DISUBSTITUTED WITH AN HETEROAROMATIC GROUP AND A SUBSTITUTED THIOCHROMANYL GROUP IN COMBINATION WITH OTHER ANTI-TUMOR AGENTS

摘要

Compounds of Formula 1 Formula 1 where the symbols have the meaning described in the specification, and particularly the compound of Formula 3 Formula 3 (tazarotene) exhibit synergistic anti-proliferative effect with human recombinant interferon in the treatment of solid tumors and leukemia, particularly breast cancer and acute myeloid leukemia.