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GPX2 A SPECIFIC AND SENSITIVE TARGET FOR LUNG CANCER DIAGNOSIS, PROGNOSIS AND/OR THERANOSIS
GPX2 A SPECIFIC AND SENSITIVE TARGET FOR LUNG CANCER DIAGNOSIS, PROGNOSIS AND/OR THERANOSIS
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机译:GPX2是肺癌诊断,预后和/或治疗学的特殊而敏感的目标
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摘要
The present invention relates in general to lung cancer and to the GPX2 gene. The present invention more specifically relates to methods of diagnosing lung cancer in a biological sample by detecting GPX2 nucleic acid or protein in the sample. In one particular embodiment, the invention relates to a method for diagnosing lung cancer in a human biological sample, the method comprising: analyzing the human biological sample for the presence of a GPX2 polynucleotide, the detection of an elevated level of GPX2 as compared to the level thereof in a normal human biological sample indicating the presence of lung cancer,. The present invention also relates to methods of diagnosing lung cancer in a biological sample by detecting GPX2 nucleic acid or protein in the sample together with a further lung cancer specific marker. In one particular embodiment the second long cancer specific marker is CALML3 nucleic acid or CALML3 protein. In one embodiment, the biological sample is obtained by a non-invasive method. In yet another embodiment of the present invention the human biological sample is selected from a sputum, a bronchial aspirate, bronchoalveolar lavage, bronchial lavage and a coughing sample. The present invention also relates to kits for diagnosing lung cancer.
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