COMPOSITIONS AND METHODS FOR EX VIVO PRESERVATION OF BLOOD VESSELS FOR VASCULAR GRAFTS USING ANALOGUES OF cAMP AND cGMP

摘要

The present invention relates to ex vivo methods for preserving/maintaining blood vessels that are to be used as vascular grafts. The present invention also relates to compositions comprising an analogue of cAMP and/or an analogue of cGMP for use in the methods of the invention, which compositions are free of: (i) an inhibitor of Type I phosphodiesterase, (ii) an inhibitor of Type II phosphodiesterase, (iii) an inhibitor of Type III phosphodiesterase, (iv) an inhibitor of Type IV phosphodiesterase, and (v) an inhibitor of TNF-α.