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GM-CSF AND/OR DEFENSIN PROTEIN EXPRESSION REGULATORS IN EPITHELIAL CELLS COMPRISING ETS TRANSCRIPTION FACTOR OR GENE ENCODING THE SAME
GM-CSF AND/OR DEFENSIN PROTEIN EXPRESSION REGULATORS IN EPITHELIAL CELLS COMPRISING ETS TRANSCRIPTION FACTOR OR GENE ENCODING THE SAME
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机译:包含ETS转录因子或编码其的基因的上皮细胞中的GM-CSF和/或防御素蛋白表达调节剂
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摘要
To solve the problem of drug tolerence and side effects in antiinflammatory agents, immunosuprressive agents and antiviral agents having been put into practical use, it is intended to provide a novel therapy for inflammation and novel antiinflammatory agents with the use of an ETS transcription factor which regulates the gene expression of an inflammartory cytokine GM-CSF and a bactericidal peptide beta -defensin. Namely, expression regulators for the inflammatory cytokine GM-CSF and /or beta -defensin in epithelial cells and antiinflammatory agents which comprise an ETS transcription factor having a gene transcription regulatory activity or a gene encoding the same, or a substance regulating the function of ETS transcription factor or a gene encoding the same, more specifically, a transcription regulatory protein myeloid Elf-1 like factor (MEF) or a gene encoding the same, or a substance regulating the function of the MEF protein or a gene encoding the same. More specifically, inflammatory cytokine GM-CSF production inhibitors, and /or regulators for beta -defensin expression due to overexpression, and antiinflammatory agents.
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