PROCESS FOR ASYMMETRIC SYNTHESIS OF HEXAHYDROPYRIMIDO1,2-A AZEPINE-2-CARBOXAMIDES AND RELATED COMPOUNDS

摘要

Processes for asymmetric synthesis of 1O(S)-amino-3-hydroxy-4-oxo-4,6,7,8,9,10­hexahydropyrimido[1,2-a]azepine-2-carboxamides and related compounds are disclosed. The enantiomerically enriched carboxamides are useful as HIV integrase inhibitors and thus are useful for treating HIV infection and AIDS.