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METHOD FOR ULTRASOUND TRIGGERED DRUG DELIVERY USING HOLLOW MICROBUBBLES WITH CONTROLLED FRAGILITY
METHOD FOR ULTRASOUND TRIGGERED DRUG DELIVERY USING HOLLOW MICROBUBBLES WITH CONTROLLED FRAGILITY
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机译:易碎的空心微泡超音速输送药物的方法
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摘要
A method is provided for site specific delivering therapeutic or diagnostic agents to a region in a fluid-filled cavity, vessel or tissue using an agent-loaded microbubble population. The population has controlled fragility characterized by a uniform wall thickness to diameter ratio which defines the discrete threshold intensity value of ultrasonic power where microbubble rupture occurs in the population. The location of the microbubble population may be monitored by ultrasound to determine its presence at the region prior to application of the ultrasonic power to rupture to microbubbles.
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