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METHODS AND COMPOSITIONS FOR THE TARGETING OF A SYSTEMIC IMMUNE RESPONSE TO SPECIFIC ORGANS OR TISSUES
METHODS AND COMPOSITIONS FOR THE TARGETING OF A SYSTEMIC IMMUNE RESPONSE TO SPECIFIC ORGANS OR TISSUES
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机译:针对特定器官或组织的全身免疫反应的定位方法和组成
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摘要
The invention provides methods and compositions for targeting a separately generated immune response to a specific organ or tissue, e.g. one affected by cancer, using one or more agents with a tropism for the organ or tissue or that can be specifically localized to the desired organ or tissue. For example, the invention provides methods ands compositions for treating liver metastases from colorectal cancer using a combination of a granulocyte/macrophage colony stimulating factor (GM-CSF) augmented tumor cell vaccination and Listeria monocytogenes (LM) infection.
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