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SCREENING COMPOUND LIBRARIES USING AN OPTICAL FIBER ARRAY DEVICE CAPABLE OF SIMULTANEOUSLY PERFORMING MULTIPLE FUNCTIONAL ASSAYS
SCREENING COMPOUND LIBRARIES USING AN OPTICAL FIBER ARRAY DEVICE CAPABLE OF SIMULTANEOUSLY PERFORMING MULTIPLE FUNCTIONAL ASSAYS
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机译:使用能够同时执行多项功能检查的光纤阵列设备来检查复合库
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摘要
Disclosed is a method of screening Compounds wherein target cells are coated onto a population of microbeads, and wherein each microbead is coated with several cells of the same cellular type and has an assay and an assay reporter associated with it. Each of the cell-coated microbeads are positioned in a well formed in one end of a fiber which is part of an array of optical fibers, and the microbeads are contacted with the compounds. The results of the assay associated with a microbead are reported to the distal end of the fiber, and each fiber in the array so reports.
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