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CONVERGENT SOLID PHASE PEPTIDE SYNTHESIS BY REACTION OF TWO FRAGMENTS BOUND TO SOLID SUPPORT
CONVERGENT SOLID PHASE PEPTIDE SYNTHESIS BY REACTION OF TWO FRAGMENTS BOUND TO SOLID SUPPORT
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机译:通过结合到固相支持物上的两个片段的反应合成聚合固相肽
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摘要
A process for preparing a peptide or protein by solid phase synthesis comprising combining a sequence including one or more amino acids obtainable by C-N synthesis linked to a first resin, with an amino acid sequence including one or more amino acid obtainable by N-C synthesis linked to a second resin so as to create a native peptide link between unprotected N and unprotected C terminals of said amino acid sequences, and optionally releasing the resulting peptide from one or more of the linked resins so as to combine with further N-C or C-N sequences or to release the desired peptide or protein sequence.
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