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USES OF VASCULAR ENDOTHELIAL GROWTH FACTOR AND TYPE I COLLAGEN INDUCIBLE PROTEIN (VCIP)
USES OF VASCULAR ENDOTHELIAL GROWTH FACTOR AND TYPE I COLLAGEN INDUCIBLE PROTEIN (VCIP)
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机译:血管内皮生长因子和I型胶原可诱导蛋白(VCIP)的用途
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摘要
Vascular endothelial growth factor and type I collagen inducible protein (VICP), also known as phosphatic acid phosphatase 2b (PAP2b), was identified in a functional assay of angiogenesis. Previously, VCIP was not known to function as an integrin ligand. The present invention discloses VCIP-derived peptides and proteins act as integrin ligands. Since VCIP-derived peptides or proteins are capable of inhibiting specific cell-cell interactions, such inhibitors of cell-cell interactions have clear pathological consequences. For example, VCIP/PAP2b can be a novel target for anti-angiogenic, anti-cancer and anti-metastatic therapy.
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