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A DELTA-12 DESATURASE GENE SUITABLE FOR ALTERING LEVELS OF POLYUN SATURATED FATTY ACIDS IN OLEAGINOUS YEASTS
A DELTA-12 DESATURASE GENE SUITABLE FOR ALTERING LEVELS OF POLYUN SATURATED FATTY ACIDS IN OLEAGINOUS YEASTS
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机译:DELTA-12脱饱和酶基因,可用于改变油脂性酵母中多饱和脂肪酸的含量
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摘要
The present invention relates to a Δ12 fatty acid desaturase able to catalyze the conversion of oleic acid to linoleic acid (LA; 18:2). Nucleic acid sequences encoding the desaturase, nucleic acid sequences that hybridize thereto, DNA constructs comprising the desaturase gene, and recombinant host microorganisms expressing increased levels of the desaturase are described. Methods of increasing production of specific ω-3 and/or ω-6 fatty acids are described by overexpression of the Δ12 fatty acid desaturase or by disruption of the native gene.
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